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COME AND JOIN US!

Senior Scientist

Microbial Generation

We are looking for a Senior Scientist to come help us cultivate unculturable microbes and maximise their commercial potential.

Role

In this role you will join our microbial generation team for the expansion of our library of novel microbes and support our vision to discover solutions to global issues including the discovery of new antibiotics against resistant bacteria and fungicides to support global food security.

Team

Our microbial generation team oversees the generation, processing, and stocking of novel species of microbes. The team currently consists of 9 microbiologists and automation specialists working closely with a group of 6 bioinformaticians.

 

Together we have used extensive data collection and a range of bioinformatics approaches to culture more than 1,800 previously unexplored microbial species.We continue to grow our library by employing a variety of sequencing approaches including whole genome sequencing, amplicon sequencing and shotgun metagenomics to strengthen our understanding of individual microbes and the soil microbiome. On top of this, we apply co-occurrence and reactome techniques to understand the relationships between individual species.

We are a diverse team, using a range of capabilities to continue to increase our cultivation rates for novel species through further technological development of the platform and automated pipelines. This allows for exploration of a greater chemical space (e.g. carbon sources, nitrogen sources) and biological space (e.g. helper strains, symbionts) to culture truly novel microbes.

Teamwork

All projects are led by individuals but supported by the entire group and discussed on a weekly basis. This model relies on people to take responsibility for their own projects, be open to discussing new ideas, and give fair and unbiased feedback. We are therefore looking for people who enjoy working in a collaborative and adaptive environment, with strong communication skills and a drive to be proactive.

Position

We are looking for a Senior Scientist to join our microbial generation team to better understand and expand microbial culturability and boost our Next Generation Sequencing (NGS) capabilities which includes: 

  • Design of large-scale NGS experiments using multiple sequencing platforms (Illumina and ONT) and differing techniques (amplicon, whole genome, metagenomics)

  • Dissect relationships between microbial communities using network analysis

  • Culturing and isolating novel microbes in the lab

  • Setting up experiments and constructing statistical models to target specific species and phyla with a limited number of experiments in almost infinite parameter space

  • Helping to increase the number of experiments via automation

  • Optional: Helping to develop bioinformatic pipelines that predict symbiotic relationships between species

 The aim over time is to be able to capture 100% of the genetic diversity from a single biome via an iterative process.

You responsibilities will include: 

  • Leading advances in our sequencing methodology and being the NGS expert across our projects

  • Designing and performing experiments to culture new microbes under a range of conditions

  • Identifying opportunities to automate the pipeline and supporting implementation to accelerate our discovery of novel solution

  • Transforming insights from machine learning into new approaches for directed evolution

  • Coordinating experiments across the microbiology team

You should have:

  • A PhD and postdoctoral experience in microbiology/sequencing/metagenomics (or equivalent experience)

  • Extensive NGS experience including using Illumina and ONT. This should cover library preparation, determining multiplexing levels on experiment-by-experiment basis and understanding downstream pipelines.

  • Experience working with microbial community data (amplicon/shotgun metagenomes)

  • Data-driven mindset and core understanding of statistical principles

  • Good understanding of bacterial culture systems (experience handling difficult-to-culture species is a plus)

  • Strong self-motivation and drive to expand our technical platform

  • Good priority management and ability to adapt

  • Collaborative drive and good team ethic

It would be great if you had:

  • Background in soil microbiology

  • Experience working with ranges of culture system

Benefits include:

  • Competitive starting salary

  • Brand new, modern labs in Central London with dedicated office space, large balconies and 360’ views of the London skyline

  • 25 days holiday + bank holidays

  • Diverse team of colleagues (check out our website to meet us)

  • Weekly team activities including board games, sports activities, and socials on Fridays

  • Complimentary breakfast, fruit, tea, coffee, snacks, drinks,...

  • Access to 1000s of training courses through Udemy, with an allowance for both personal development and work-related training

  • Opportunity to use your skills to help shape our innovative platform

Are you interested in joining us?
Send us your CV and an introductory paragraph using the link below

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