We use next generation sequencing
to understand which microbes grow together
We use next generation sequencing to understand which microbes grow together
Genomics (NGS)
We use data science to understand how
these microbes grow together
We use data science to understand how these microbes grow together
DoE/Automation
We use synthetic biology to isolate and grow our new microbes in the laboratory
We use synthetic biology to isolate and grow our new microbes in the laboratory
Synthetic Biology
MICROBIAL GENERATION PLATFORM
Microbes grow in complex communities
There are 10.000 microbial species in a gram of soil. These microbes grow in parallel micro-communities that have specific growth requirements
RESULTS
We have cultured 800 new microbial species
Our microbes constitute 5% of all microbial species ever cultured and exist in new pockets of genetic and chemical space
Bactobio’s microbial collection
World culture collections
Bactobio’s microbial collection
World culture collections
We use DNA sequencing, machine learning,
and synthetic biology to culture novel microbes
We screen our novel microbes for chemicals that make the world greener and safer
We use bioinformatics, among other things, to identify which of our microbes have the highest chance of producing novel antimicrobials that target a specified pathogen
We use bioinformatics, among other things, to identify which of our microbes have the highest chance of producing novel antimicrobials that target a specified pathogen
Bioinformatics
We use molecular chemistry to build sensitive and miniaturised assays that we automate for high throughput
We use molecular chemistry to build sensitive and miniaturised assays that we automate for high throughput
Screening
We use analytical chemistry and chemoinformatics to efficiently identify the responsible antimicrobial compound
We use analytical chemistry and chemoinformatics to efficiently identify the responsible antimicrobial compound
Chemoinformatics
DISCOVERY PLATFORM
Our novel microbes are screened for novel antimicrobials against human & plant diseases
Each novel microbe produces thousands of compounds – most of these compounds have no known function or commercial potential. We have developed a pipeline to quickly identify novel chemistry with real-world impact
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