We use next generation sequencing
to understand which microbes grow together
We use next generation sequencing to understand which microbes grow together
Genomic (NGS)
We use data science to understand how
these microbes grow together
We use data science to understand how these microbes grow together
DoE/Automation
We use synthetic biology to isolate and grow our new microbes in the laboratory
We use synthetic biology to isolate and grow our new microbes in the laboratory
Synthetic Biology
MICROBIAL GENERATION PLATFORM
Microbes grow in complex communities
There are 10.000 microbial species in a gram of soil. These microbes grow in parallel micro-communities that have specific growth requirements
RESULTS
We have cultured 800 new microbial species
Our microbes constitute 5% of all microbial species ever cultured and exist in new pockets of genetic and chemical space
Bactobio’s microbial collection
World culture collections
Bactobio’s microbial collection
World culture collections
We use DNA sequencing, machine learning,
and synthetic biology to culture novel microbes
We screen our novel microbes for chemicals that make the world greener and safer
We express the responsible biosynthetic gene clusters in heterologous organisms to upregulate and purify antimicrobials
We express the responsible biosynthetic gene clusters in heterologous organisms to upregulate and purify antimicrobials
Bioinformatics
We screen our novel species in high throughput to identify species and later biosynthetic gene clusters that produce antimicrobials
We screen our novel species in high throughput to identify species and later biosynthetic gene clusters that produce antimicrobials
Screening
We ensure that our antimicrobials are novel by comparing them to known structures using our evolving dereplication pipeline
We ensure that our antimicrobials are novel by comparing them to known structures using our evolving dereplication pipeline
Chemoinformatics
DISCOVERY PLATFORM
Our novel microbes are screened for novel antimicrobials against human & plant diseases
We combine automation, molecular biology, and analytical chemistry to isolate and identify our novel antimicrobials
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