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We use next generation sequencing

to understand which microbes grow together

We use next generation sequencing to understand which microbes grow together

Genomic (NGS)

We use data science to understand how
these microbes grow together

We use data science to understand how these microbes grow together

DoE/Automation

We use synthetic biology to isolate and grow our new microbes in the laboratory

We use synthetic biology to isolate and grow our new microbes in the laboratory

Synthetic Biology

MICROBIAL GENERATION PLATFORM

Microbes grow in complex communities

There are 10.000 microbial species in a gram of soil. These microbes grow in parallel micro-communities that have specific growth requirements

RESULTS

We have cultured 800 new microbial species

Our microbes constitute 5% of all microbial species ever cultured and exist in new pockets of genetic and chemical space

Bactobio’s microbial collection

World culture collections

Bactobio’s microbial collection

World culture collections

We use DNA sequencing, machine learning,
and synthetic biology to culture novel microbes

We screen our novel microbes for chemicals that make the world greener and safer

We express the responsible biosynthetic gene clusters in heterologous organisms to upregulate and purify antimicrobials

We express the responsible biosynthetic gene clusters in heterologous organisms to upregulate and purify antimicrobials

Bioinformatics

We screen our novel species in high throughput to identify species and later biosynthetic gene clusters that produce antimicrobials

We screen our novel species in high throughput to identify species and later biosynthetic gene clusters that produce antimicrobials

Screening

We ensure that our antimicrobials are novel by comparing them to known structures using our evolving dereplication pipeline

We ensure that our antimicrobials are novel by comparing them to known structures using our evolving dereplication pipeline

Chemoinformatics

DISCOVERY PLATFORM

Our novel microbes are screened for novel antimicrobials against human & plant diseases

We combine automation, molecular biology, and analytical chemistry to isolate and identify our novel antimicrobials

If you want to work with us please

RESULTS

We accept projects based on impact and can find antimicrobials targeting any human/plant microbial pathogen

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